L-Tyrosine Uses, Side Effects & Warnings (2024)

Generic name: tyrosine [TYE-roe-seen]
Drug class: Oral nutritional supplements

Medically reviewed by Drugs.com on Mar 29, 2024. Written by Cerner Multum.

What is L-Tyrosine?

L-Tyrosine is an amino acid, which is a building block of protein that occurs naturally in the body. L-Tyrosine can also be found in certain foods such as meat, fish, eggs, dairy products, beans, nuts, oats, and wheat.

Some people have low levels of L-Tyrosine in their bodies because of a hereditary condition called phenylketonuria (PKU). In people with PKU, the body cannot process an amino acid called phenylalanine, which the body needs to produce L-Tyrosine.

L-Tyrosine is given as a supplement to increase L-Tyrosine levels in people with PKU.

L-Tyrosine has been used in alternative medicine as a possibly effective aid in improving mental performance, alertness, or memory.

L-Tyrosine has also been used to treat depression or attention deficit disorder (ADD or ADHD). However, research has shown that L-Tyrosine may not be effective in treating these conditions. L-Tyrosine also may not be be effective in improving exercise performance.

Other uses not proven with research have included dementia, high blood pressure, narcolepsy, schizophrenia, weight loss, premenstrual syndrome, Parkinson's disease, chronic fatigue syndrome, alcoholism, cocaine addiction, and other conditions.

It is not certain whether L-Tyrosine is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. L-Tyrosine should not be used in place of medication prescribed for you by your doctor.

L-Tyrosine is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

L-Tyrosine may also be used for purposes not listed in this product guide.

Related/similar drugs

acetylcysteine, ascorbic acid, biotin, Vitamin C, multivitamin, Dextrose

L-Tyrosine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, L-Tyrosine is thought to be likely safe in most adults when taken for up to 3 months.

Common side effects of L-Tyrosine may include:

  • nausea, heartburn;

  • headache;

  • joint pain; or

  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

L-Tyrosine side effects (more detail)


Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Before using L-Tyrosine, talk to your healthcare provider. You may not be able to use L-Tyrosine if you have certain medical conditions, especially:

  • overactive thyroid; or

  • Graves disease.

It is not known whether L-Tyrosine will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

It is not known whether tyrosine passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

How should I take L-Tyrosine?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use L-Tyrosine, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Your dose of L-Tyrosine will depend on the amount of protein you consume in your diet. Follow your doctor's dosing instructions very carefully.

L-Tyrosine is only part of a complete program of treatment that may also include a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you must eat or avoid to help control your condition.

Call your doctor if the condition you are treating with L-Tyrosine does not improve, or if it gets worse while using this product.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra L-L-Tyrosine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking L-Tyrosine?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect L-Tyrosine?

Do not take L-Tyrosine without medical advice if you are using any of the following medications:

  • levodopa; or

  • thyroid replacement (Synthroid, Levothroid, and others).

This list is not complete. Other drugs may interact with tyrosine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this product guide.

L-Tyrosine drug interactions (more detail)

More about L-Tyrosine (tyrosine)

  • Check interactions
  • Compare alternatives
  • Reviews (7)
  • Side effects
  • Drug class: oral nutritional supplements
  • En español

Related treatment guides

  • Dietary Supplementation

Further information

  • Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

Copyright 1996-2024 Cerner Multum, Inc. Version: 1.01.

L-Tyrosine Uses, Side Effects & Warnings (2024)


L-Tyrosine Uses, Side Effects & Warnings? ›

When taken by mouth: Tyrosine is commonly consumed in foods. Tyrosine is possibly safe when taken as a medicine, short-term. It seems to be safe when taken in doses up to 150 mg/kg daily for up to 3 months. Some people experience side effects such as nausea, headache, fatigue, and heartburn.

What are the negative side effects of L-tyrosine? ›

Common side effects of L-Tyrosine may include:
  • nausea, heartburn;
  • headache;
  • joint pain; or.
  • feeling tired.
Mar 29, 2024

Who should not use L-tyrosine? ›

People who have migraine headaches should avoid tyrosine, as it can trigger migraine headaches and stomach upset. People with hyperthyroidism or Graves disease should avoid tyrosine supplements because tyrosine may increase levels of thyroid hormone.

Does L-tyrosine affect blood pressure? ›

Tyrosine injection appears to reduce blood pressure via an action within the central nervous system, since the effect can be blocked by co-administering other large neutral amino acids that reduce tyrosine's uptake into the brain.

What are the immediate effects of tyrosine? ›

The effects of L-tyrosine may not be immediate unless your dopamine levels are depleted. It may take several weeks for you to notice any changes in your symptoms. If you don't notice any improvement after a few weeks, you may want to try a higher dose or talk to your doctor about other treatment options.

Can L-tyrosine damage the liver? ›

Tyrosine is an amino acid that is found in most proteins. When people with tyrosinemia break down protein, abnormal toxic break down products of tyrosine build up in their bodies. This causes progressive damage to the liver and kidneys, but mainly the liver.

Is tyrosine safe for kidneys? ›

Side effects, toxicity, and interactions

It can make your kidneys work harder. In children, single amino acid supplements may cause growth problems. You should not take high doses of single amino acids for long periods of time.

What disorders are associated with tyrosine? ›

Tyrosine Metabolism Disorders
  • Transient Tyrosinemia of the Newborn|
  • Tyrosinemia Type I|
  • Tyrosinemia Type II|
  • Alkaptonuria|
  • Oculocutaneous Albinism|
  • More Information.

Can you take L-tyrosine and magnesium together? ›

Interactions between your drugs

No interactions were found between L-Tyrosine and magnesium threonate.

What is the difference between tyrosine and L-tyrosine? ›

L-tyrosine (also referred to as tyrosine) is an amino acid. It is considered a nonessential amino acid since the body can make tyrosine from another amino acid, phenylalanine. It is one of several amino acids, the building blocks of proteins. It is involved in the structure of almost all proteins in the body.

Can L-tyrosine cause heart problems? ›

Small doses of tyrosine produce tachycardia and hypertension while higher doses produce bradycardia and hypotension in anaesthetised rats. The mechanism of these effects has not been established. An increased synthesis and release of catecholamines has been suggested to be the mechanism.

Does L-tyrosine cause weight gain? ›

Can tyrosine cause weight gain? It shouldn't, even if it doesn't necessarily lead to weight loss or influence your appetite. However, there is evidence that among people needing to gain weight, such as those recovering from anorexia, it may help improve appetite, cognition and exercise tolerance.

Does L-tyrosine affect sleep? ›

Taking 150 mg/kg of tyrosine seems to help people who have lost a night's sleep stay alert for about 3 hours longer than they otherwise would. Also, early research suggests that tyrosine improves memory and reasoning in people who are sleep-deprived.

What should you not mix L-tyrosine with? ›

Levodopa(L-dopa) -- No one should take tyrosine at the same time as levodopa, a medication used to treat Parkinson's disease because levodopa may interfere with the absorption of tyrosine.

What are the symptoms of low L-tyrosine? ›

The most common signs of l-tyrosine deficiency includes flu-like symptoms such as fatigue, swollen joints, aching muscles and pale skin. A lack of interest in recreational activities is also an indication that you may benefit from l-tyrosine supplements.

How does L-tyrosine make you feel? ›

May help in stressful situations

In one example, participants who performed a test that measured their cognitive flexibility did better when taking an L-tyrosine supplement versus a placebo. Another study shows that people who worked on a mentally demanding task saw their working memory improve while taking L-tyrosine.

Can L-tyrosine cause weight gain? ›

Can tyrosine cause weight gain? It shouldn't, even if it doesn't necessarily lead to weight loss or influence your appetite. However, there is evidence that among people needing to gain weight, such as those recovering from anorexia, it may help improve appetite, cognition and exercise tolerance.

Does L-tyrosine deplete serotonin? ›

L-tyrosine may reduce serotonin, 5-HTP and sulphur amino acid. L-dopa may reduce serotonin, L-tryptophan L-tyrosine and sulphur-containing amino acids. L-tryptophan may reduce dopamine. Sulphur amino acids may reduce dopamine and serotonin.

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